[Chemgood 한국공식대리점] PLX-5622 제품소개

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[Chemgood] PLX-5622

Product Information:

Product Name: PLX-5622
Catalog#: C-1521
Targets: CSF-1R
Synonym: PLX-5622; PLX5622; PLX 5622
Chemical Name/IUPAC: 3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-
SMILES Code: CC1=CN=C2C(C(CC3=C(F)N=C(NCC4=CC(F)=CN=C4OC)C=C3)=CN2)=C1
Chemical Formula: C21H19F2N5O
Molecular Weight: 395.41
CAS#: 1303420-67-8
Appearance: Solid powder
Purity: > 99% by HPLC
Solubility: Soluble in DMSO
Storage: Room temperature for months, or -20ºC for 3 years

Product Description:

PLX-5622 is a highly selective brain-penetrant CSF1R inhibitor (IC50=0.016 µM; Ki=5.9 nM) allowing for extended and specific microglial elimination, preceding and during pathology development.

Key Features: CSF1R Inhibition: PLX-5622 selectively targets and inhibits CSF1R, which is essential for the survival and function of microglia. This leads to a reversible depletion of microglia in animal models.

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[Chemgood 한국공식대리점] PLX-5622 제품소개

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[Chemgood] PLX-5622

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